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Open Access Article

JCIM. 2021; 1: (2) ; 100-101,123 ; DOI: 10.12208/j.ddjryx.2021.02.042.

Observation of the Curative Effect of Bleomycin Combined with Temozolomide on Glioma
博来霉素联合替莫唑胺治疗胶质瘤的疗效观察研究

作者: 刘海峰*, 兰杰, 吴静

南宁市第一人民医院

*通讯作者: 刘海峰,单位:南宁市第一人民医院;

发布时间: 2021-01-25 总浏览量: 148

摘要

目的:研究对胶质瘤给予博来霉素联合替莫唑胺治疗的临床效果。方法:选取2015年1月~2018年1月海口市人民医院收治的60例脑胶质瘤患者,使用随机数字表法分为两组,各30例,采取替莫唑胺治疗为参照组,采取博来霉素联合替莫唑胺治疗为治疗组,对比两组疗效。结果:对比参照组,治疗组有效率、疾病控制率、1年生存率均较高(P<0.05);治疗前,两组肿瘤患者生活质量评分(QOL)、卡式评分(KPS)评分对比无差异(P>0.05),治疗后,治疗组对比参照组评分均较高(P<0.05)。结论:对脑胶质瘤患者给予博来霉素联合替莫唑胺治疗可稳定病情,延长患者生存期,进而改善其健康状态,提升其生活质量,值得借鉴。

关键词: 博来霉素;替莫唑胺;脑胶质瘤;生存期

Abstract

Objective:To study the clinical effect of bleomycin combined with temozolomide in the treatment of glioma.
Methods:From January 2015 to January 2018,60 patients with brain glioma admitted to Haikou People's Hospital were selected and divided into two groups using random number table method,30 patients in each group.Temozolomide treatment was used as the reference group,and blenomycin combined with temozolomide treatment was used as the treatment group,and the efficacy of the two groups was compared.
Results:Compared with the reference group,the effective rate,disease control rate and 1-year survival rate were higher in the treatment group(P<0.05).Before treatment,there was no difference in QOL and KPS scores between the two groups(P>0.05).After treatment,the scores of the treatment group were higher than that of the reference group(P<0.05).
Conclusion  :Bleomycin combined with temozolomide can stabilize glioma patients,prolong their survival time,improve their health status and improve their quality of life,which is worthy of reference.

Key words: Bleomycin;Temozolomide;Glioma;The Lifetime

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引用本文

刘海峰, 兰杰, 吴静 博来霉素联合替莫唑胺治疗胶质瘤的疗效观察研究[J]. 当代介入医学, 2021; 1: (2) : 100-101,123.