摘要
目的：探讨来源于大绿臭蛙，序列为EHVSEVGDILALSDT的新型多肽OL-EH15对口腔溃疡大鼠的治疗作用。方法：建立30例大鼠口腔溃疡模型，随机分为阴性对照组(生理盐水处理)、阳性对照(西瓜霜喷剂处理)、实验组(100μg/mL OL-EH15处理)，1周内观察大鼠口腔溃疡程度，愈合情况。结果：相比于阴性对照组和阳性对照组，OL-EH15的处理能够显著改善大鼠口腔溃疡，促进口腔黏膜愈合。结论：新型多肽对口腔溃疡大鼠有较好的治疗作用，值得临床推广使用。
关键词： 口腔溃疡；大绿臭蛙；新型多肽
Abstract
Objective:To investigate the therapeutic effect of a new peptide OL-EH15(EHVSEVGDILALSDT)derived from odorrana livida,on oral ulcer rats.Methods:30 oral ulcer models of rats were established,and they were randomly divided into negative control group(saline treatment),positive control(watermelon frost spray treatment),and experimental group(100μg/mL RL-EH15 treatment) respectively.The degree of oral ulcers and healing in rats are examined.Results:Compared with the negative control group and the positive control group,RL-EH15 treatment significantly alleviates rat oral ulcers and promotes oral mucosal healing.Conclusion :The new polypeptide has a good therapeutic effect on rats with oral ulcers and is worthy of clinical application.
Key words： oral ulcer,odorrana livida,new peptide
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