欢迎来到OAJRC平台!

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

JCIM. 2021; 1: (2) ; 8-9 ; DOI: 10.12208/j.ddjryx.2021.02.003.

Effect of Peptide RL-EH15 on Oral Ulcer in Rats
新型多肽OL-EH15对大鼠口腔溃疡的治疗作用

作者: 罗茗丹, 徐娟, 王广, 鲁小芳, 何川*,

云南昂肽生物科技有限公司

*通讯作者: 何川,单位:云南昂肽生物科技有限公司;

发布时间: 2021-01-25 总浏览量: 169

摘要

目的:探讨来源于大绿臭蛙,序列为EHVSEVGDILALSDT的新型多肽OL-EH15对口腔溃疡大鼠的治疗作用。方法:建立30例大鼠口腔溃疡模型,随机分为阴性对照组(生理盐水处理)、阳性对照(西瓜霜喷剂处理)、实验组(100μg/mL OL-EH15处理),1周内观察大鼠口腔溃疡程度,愈合情况。结果:相比于阴性对照组和阳性对照组,OL-EH15的处理能够显著改善大鼠口腔溃疡,促进口腔黏膜愈合。结论:新型多肽对口腔溃疡大鼠有较好的治疗作用,值得临床推广使用。

关键词: 口腔溃疡;大绿臭蛙;新型多肽

Abstract

Objective:To investigate the therapeutic effect of a new peptide OL-EH15(EHVSEVGDILALSDT)derived from odorrana livida,on oral ulcer rats.
Methods:30 oral ulcer models of rats were established,and they were randomly divided into negative control group(saline treatment),positive control(watermelon frost spray treatment),and experimental group(100μg/mL RL-EH15 treatment) respectively.The degree of oral ulcers and healing in rats are examined.
Results:Compared with the negative control group and the positive control group,RL-EH15 treatment significantly alleviates rat oral ulcers and promotes oral mucosal healing.
Conclusion  :The new polypeptide has a good therapeutic effect on rats with oral ulcers and is worthy of clinical application.

Key words: oral ulcer,odorrana livida,new peptide

参考文献 References

[1]Jiang H,Yu X,Fang R,Xiao Z,Jin Y.3D printed mold-based capsaicin candy for the treatment of oral ulcer[J].International journal of pharmaceutics,2019,568:118517.

[2]杨新旺,李文辉,张云.臭蛙皮肤中分布有高丰度的新型抗氧化肽[C]//第十一届中国生物毒素研究及医药应用年会,2013.

[3]孔红梅,张广慧.治疗口腔溃疡的几种简易疗法[J].中国社区医师:医学专业,2004,5(7):34-34.

[4]张建丽,胡杰,刘翠峰.金莲花胶囊联合大蒜素胶囊治疗复发性口腔溃疡的临床研究[J].现代药物与临床,2019,34(04):1120-1124.

[5]Nodai T,Hitomi S,Ono K,et al.Endothelin-1 Elicits TRP-Mediated Pain in an Acid-Induced Oral Ulcer Model[J].Journal of dental research,2018,97(8):901-908.

[6]王芳,杨洪菊,WANG,等.护理作业书对管理和控制肿瘤患者不适症状的效果研究[J].泰山医学院学报,2017,8(38):77-79.

[7]Yunhao,Gu,Yixin,et al.Vitamin B_2 functionalized iron oxide nanozymes for mouth ulcer healing[J].Science China(Life Sciences),2020,63(01):70-81.

[8]Piva RM,Johann ACBR,Costa CK,et al.Bixin Action in the Healing Process of Rats Mouth Wounds[J].Current Pharmaceutical Biotechnology,2013,14(9):785-791.

[9]刘存宝.大绿臭蛙皮肤抗氧化肽antioxidin-RL的分离纯化及结构和功能研究[D].北京:中国科学院研究生院,2012.


引用本文

罗茗丹, 徐娟, 王广, 鲁小芳, 何川, 新型多肽OL-EH15对大鼠口腔溃疡的治疗作用[J]. 当代介入医学, 2021; 1: (2) : 8-9.