Open Access Article
JCIM. 2021; 1: (1) ; 16-18 ; DOI: 10.12208/j.ddjryx.2021.0007.
Expression of KDM5B in Epithelial Ovarian Carcinoma and Its Clinical Significance
KDM5B在卵巢上皮性癌组织中的表达及其临床意义
作者：
李传棠 *
广州市增城区人民医院
*通讯作者：
李传棠,单位：广州市增城区人民医院；
发布时间: 2021-01-10 总浏览量: 491
PDF 全文下载
引用本文
摘要
目的：探讨KDM5B在卵巢上皮性癌(Epithelial ovarian carcinoma,EOC)组织中的表达及其临床意义。方法：免疫组化检测KDM5B在55例EOC组织和20例正常卵巢组织中的表达水平，分析其与临床病理特征的关系，利用Kaplan-Meier plotter分析KDM5B表达与EOC患者预后的相关性。结果：EOC组织中阳性表达率比正常卵巢组织高，差异具有显著性(P＜0.05)；KDM5B在EOC组织中的表达与腹水、远处转移、病理分级及病理分期显著相关(P＜0.05)；KDM5B的表达与EOC患者的总生存期(P＜0.05)和无病生存期(P＜0.05)均有相关性，EOC组织中KDM5B表达越高，患者总生存时间和无病生存时间越短。结论：KDM5B在EOC组织中高表达，其与EOC的生物学行为和患者预后生存密切相关。
关键词： KDM5B；生物学行为；卵巢上皮性癌；预后
Abstract
Objective:To investigate the expression of KDM5B in epithelial ovarian carcinoma(EOC)and its clinical significance.Methods:The expression level of KDM5B in 55 EOC tissues and 20 normal ovarian tissues was detected by immunohistochemistry,and its relationship with clinicopathological characteristics was analyzed.Kaplan-Meier plotter was used to analyze the correlation between KDM5B expression and the prognosis of EOC patients.Results:The positive expression rate in EOC tissue was higher than that in normal ovarian tissue,and the difference was significant(P＜0.05);the expression of KDM5B in EOC tissue was significantly related to ascites,distant metastasis,pathological grade and pathological stage(P＜0.05);The expression of KDM5B is correlated with the overall survival(P<0.05)and disease-free survival(P<0.05)of EOC patients.The higher the expression of KDM5B in EOC tissues,the shorter the overall survival time and disease-free survival time of patients.Conclusion :KDM5B is highly expressed in EOC tissues,and it is closely related to the biological behavior of EOC and the prognosis of patients.
Key words： KDM5B;biological behavior;epithelial ovarian cancer;prognosis
参考文献 References
[1]
[2]
[3]
[4]
[5]
[6]
引用本文
李传棠, KDM5B在卵巢上皮性癌组织中的表达及其临床意义[J]. 当代介入医学, 2021; 1: (1) : 16-18.