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Open Access Article

JCIM. 2021; 1: (1) ; 16-18 ; DOI: 10.12208/j.ddjryx.2021.0007.

Expression of KDM5B in Epithelial Ovarian Carcinoma and Its Clinical Significance
KDM5B在卵巢上皮性癌组织中的表达及其临床意义

作者: 李传棠*,

广州市增城区人民医院

*通讯作者: 李传棠,单位:广州市增城区人民医院;

发布时间: 2021-01-10 总浏览量: 189

摘要

目的:探讨KDM5B在卵巢上皮性癌(Epithelial ovarian carcinoma,EOC)组织中的表达及其临床意义。方法:免疫组化检测KDM5B在55例EOC组织和20例正常卵巢组织中的表达水平,分析其与临床病理特征的关系,利用Kaplan-Meier plotter分析KDM5B表达与EOC患者预后的相关性。结果:EOC组织中阳性表达率比正常卵巢组织高,差异具有显著性(P<0.05);KDM5B在EOC组织中的表达与腹水、远处转移、病理分级及病理分期显著相关(P<0.05);KDM5B的表达与EOC患者的总生存期(P<0.05)和无病生存期(P<0.05)均有相关性,EOC组织中KDM5B表达越高,患者总生存时间和无病生存时间越短。结论:KDM5B在EOC组织中高表达,其与EOC的生物学行为和患者预后生存密切相关。

关键词: KDM5B;生物学行为;卵巢上皮性癌;预后

Abstract

Objective:To investigate the expression of KDM5B in epithelial ovarian carcinoma(EOC)and its clinical significance.
Methods:The expression level of KDM5B in 55 EOC tissues and 20 normal ovarian tissues was detected by immunohistochemistry,and its relationship with clinicopathological characteristics was analyzed.Kaplan-Meier plotter was used to analyze the correlation between KDM5B expression and the prognosis of EOC patients.
Results:The positive expression rate in EOC tissue was higher than that in normal ovarian tissue,and the difference was significant(P<0.05);the expression of KDM5B in EOC tissue was significantly related to ascites,distant metastasis,pathological grade and pathological stage(P<0.05);The expression of KDM5B is correlated with the overall survival(P<0.05)and disease-free survival(P<0.05)of EOC patients.The higher the expression of KDM5B in EOC tissues,the shorter the overall survival time and disease-free survival time of patients.
Conclusion  :KDM5B is highly expressed in EOC tissues,and it is closely related to the biological behavior of EOC and the prognosis of patients.

Key words: KDM5B;biological behavior;epithelial ovarian cancer;prognosis

参考文献 References

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引用本文

李传棠, KDM5B在卵巢上皮性癌组织中的表达及其临床意义[J]. 当代介入医学, 2021; 1: (1) : 16-18.